Lecture Prof. Slagboom

15 February 2017

Lecture Professor P. Eline Slagboom

Professor P. Eline SlagboomDate | time: 15 February 2017 | 14:00-15:00 hrs.
Location: UNS 60, lecture hall 2, M0.09

Prof. P. Eline Slagboom - professor of Molecular Epidemiology at the Leiden University Medical Center (LUMC) and an expert in the field of genetic, epigenetic, transcriptomic and metabolomic studies of healthy/unhealthy ageing and longevity in humans - will give a lecture entitled Healthy Ageing studies: connecting epidemiology, biology and the clinic.

Despite the continuous increase in life expectancy in our societies, the diversity in health span is enormous, ranging from unhealthy 60- to vital 90-year-olds and displays considerable gender effects (http://ec.europa.eu/health/indicators). The diversity in the rate and nature of physiological decline among elderly is to a great extend driven by changes in metabolism and immunity. This diversity especially at higher ages is poorly marked and understood and obscures the effect of interventions and treatments.

Traditionally metabolic health is measured by serum insulin and lipids, blood pressure and BMI, but among the fastest growing population of elderly the predictive power of these parameters declines. The omics field is making progress in recording changes in metabolite composition, glycosylation, transcriptome and epigenetic regulation of the nuclear and mitochondrial genome, gut microbiome composition and somatic DNA sequence changes with ageing. In our attempts to use such data as biomarker in research on age-related disease and longevity we witness the signatures of early development in addition to age-related changes.  We measured biobanked material from population and patient based studies as well as from intervention studies by using a single metabolomics platform. We investigated 30.000 individuals to record the association of generic and specific metabolite profiles to a variety of diseases, to healthy ageing and to mortality. We will discuss how the results may be used in practice and what future work needs to be done to make metabolomics markers assist in the development of personalised medicine.

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